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Basic Estrogel Guide
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<h1>DIY Estrogel Guide</h1>
<p>This guide will instruct you on the materials and tools needed for home DIY basic estrogel compounding. There are easier methods out there, such as mixing estradiol into pre-made hand sanitizers, but this is for those who would prefer to compound their own gels, or manufacture at a scale where buying hand sanitizer is cost prohibitive. There are also some concerns about hand sanitizer formulations containing denaturing agents or other additives that might be bad for transdermal drug delivery. If you are interested in more experimental gel formulations or ones based on hand sanitizer, you can check out reddit.com/r/estrogel/wiki, which is where I got most of this information. <br/><br/>With this guide, you can produce supersaturated estrogels that are suitable for high-dose estradiol monotherapy. This is a great alternative to injections for the needle-shy or paranoid. <br/><br/>This recipe is based off of a patent that includes a generic estrogel recipe, available here: <a href="https://patents.google.com/patent/US20070154533A1/en" rel="nofollow noopener" target="_blank">https://patents.google.com/patent/US20070154533A1/en</a> - page 39 of the PDF has the recipe. This recipe has been adjusted for higher concentrations and higher absorption, using 60% ethanol, which is known to have the best absorption for estradiol. (<a href="https://sci-hub.se/https://doi.org/10.1016/j.addr.2012.09.032" rel="nofollow noopener" target="_blank">https://sci-hub.se/https://doi.org/10.1016/j.addr.2012.09.032</a>)</p>
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<h3>Usage/my results</h3>
<p>With the bottles I recommend, each pump will dispense about 225mg of gel, or .5mg per pump. I used 4 pumps a day at first, putting 1 pump on my scrotum, and 1 on my thigh, morning and night, and after a month of this, I had the following blood test results:<br/>Testosterone: 29 ng/dL<br/>Estradiol: 326 pg/mL<br/><br/>I am currently lowering my dose to 2 pumps a day, on the scrotum only, to see if 1mg scrotally is enough for monotherapy. I will report back once I have blood test results. Although conventional wisdom with transdermal delivery says that transdermal gels have a depot effect, scrotal application has not been studied much and it could be the case that absorption is much quicker, so to be safe I apply twice a day rather than using 2 pumps once a day, and I also get my blood tests done at trough (before I do my morning dose).<br/><br/>This is a promising alternative to injections, and because it&#39;s alcohol based, the risk of contamination is low, even without a clean room or heat sterilization. This is also a great alternative for those who are needle-phobic or are for some reason not wanting to do injections. <br/><br/>[contact info removed at request of the author]</p>
<p>Discussion: <a href="https://groups.io/g/MTFHRT/topic/wiki_article_about_estrogel/93220481" rel="nofollow noopener" target="_blank">https://groups.io/g/MTFHRT/topic/wiki_article_about_estrogel/93220481</a></p>
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