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diyhrt.market/transfem-hrt-guide.html
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@@ -261,7 +261,7 @@ Standard Adult Female Range: 0.8-3.1 nmol/L<br>
<p>A starting Estradiol dose of 3-4mg/day will work for most though this should be tweaked in response to blood tests. For blockers 12.5mg/day Cyproterone, 50mg/day Bicalutamide or 200mg Spironolactone will do the job, no testing necessary.</p>
<p>As a final note there&rsquo;s <a href="https://transfemscience.org/articles/genital-e2-application/">a common suggestion</a> floating around the community that gels can be applied to the scrotum for optimal absorption. This isn&rsquo;t an old wive&rsquo;s tail, there is a study showing higher absorption and it&rsquo;s well studied with Testosterone however it also results in a much greater spike. It&rsquo;s a higher level shortly after, but it also falls off a lot faster which works against our goal of stable levels. If you want higher levels then just take a higher dose, it&rsquo;s that simple, there&rsquo;s no need to cheat.</p>
<h4 id="estradiol-gels-plus-blockers">Estradiol Pills + Blockers</h4>
<p>The main downsides of Estradiol pills compared to other administration methods are extremely poor absorption and rapid elimination from your system, approximately 90% of it is destroyed in the liver and it&rsquo;s entirely out of your system within 24-36 hours. This results in needing to take relatively large doses multiple times per day to maintain target levels.</p>
<p>The main downsides of Estradiol pills compared to other administration methods are extremely poor absorption and rapid elimination from your system, most of it is destroyed in the liver and it&rsquo;s entirely out of your system within 24-36 hours. This results in needing to take relatively large doses multiple times per day to maintain target levels.</p>
<p>Pills should be taken at least twice per day, ideally thrice. If taken once per day in the morning you&rsquo;ll find yourself towards the end of the day feeling quite lethargic and though it&rsquo;s not been studied or quantified this almost certainly negatively impacts feminisation since you&rsquo;re below target levels for most of the day.</p>
<p>Sublingual pills (allowing them to dissolve under the tongue and be absorbed) aren&rsquo;t recommended for essentially the same reason as explained above with scrotal gel application. It does circumvent much of the destruction in the liver but it also flushes through the system even faster which is already a problem with pills. Again if you want higher levels it&rsquo;s better to just take a higher oral dose.</p>
<p>An Estradiol dose of 4-6mg/day is a good starting point. The pills are almost universally 2mg, so one pill every 12 hours or every 8 hours is the way to go. When getting blood tests try to get it taken as close to the trough as possible, right before your next pill.</p>
@@ -387,5 +387,5 @@ DIYHRT.Market 2022-2024
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