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@@ -129,7 +129,7 @@ if (false) {
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@@ -985,9 +985,9 @@ function createAlert(msg, isError, autoClose, noClose) {
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<div class="col-sm-12">
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<span class="wikidisplay user-content">
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<p style="text-align: center;"><span style="font-size: 24pt;">MtF HRT: Ultimate DIY</span></p>
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<p style="text-align: center"><span style="">MtF HRT: Ultimate DIY</span></p>
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<p>Here I describe Do-It-Yourself hormonal treatment for male-to-female transsexuals: be your own gatekeeper, endocrinologist, pharmacist and nurse. Cook injectable estradiol by yourself. Safer, more effective and unbelievably cheaper than relying on medical professionals.</p>
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<p style="text-align: right;"><a href="https://groups.io/g/TGrus/wiki/Ultimate-DIY" target="_blank" rel="nofollow noopener">эта инструкция по-русски</a></p>
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<p style="text-align: right"><a href="https://groups.io/g/TGrus/wiki/Ultimate-DIY" target="_blank" rel="nofollow noopener">эта инструкция по-русски</a></p>
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<p></p><div class="row">
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<div class="col-sm-12">
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<div class="panel panel-default">
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@@ -997,7 +997,7 @@ function createAlert(msg, isError, autoClose, noClose) {
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</h4>
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</div>
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<div id="collapseTOC" class="panel-collapse collapse in">
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<div class="panel-body" style="padding-left:0px;"><span class="toc"><ol style=""><li><a href="173933.html#Without-gatekeepers" rel="nofollow">Without gatekeepers</a></li><li><a href="173933.html#Be-your-own-endocrinologist" rel="nofollow">Be your own endocrinologist</a></li><li><a href="173933.html#Cook-your-injectable-estradiol-by-yourself" rel="nofollow">Cook your injectable estradiol by yourself</a><ol style=""><li><a href="173933.html#Buy-estradiol-enanthate-powder" rel="nofollow">Buy estradiol enanthate powder</a></li><li><a href="173933.html#Equipment" rel="nofollow">Equipment</a><ol style=""><li><a href="173933.html#Necessary" rel="nofollow">Necessary</a></li><li><a href="173933.html#Optional" rel="nofollow">Optional</a></li><li><a href="173933.html#Unnecessary" rel="nofollow">Unnecessary</a></li></ol></li><li><a href="173933.html#Other-raw-materials-and-expendables" rel="nofollow">Other raw materials and expendables</a><ol style=""><li><a href="173933.html#Vials2C-stoppers2C-caps" rel="nofollow">Vials, stoppers, caps</a></li><li><a href="173933.html#Oil" rel="nofollow">Oil</a></li><li><a href="173933.html#Preservative-28optional29" rel="nofollow">Preservative (optional)</a></li><li><a href="173933.html#Syringes-for-mixing" rel="nofollow">Syringes for mixing</a></li></ol></li><li><a href="173933.html#Mix" rel="nofollow">Mix</a></li><li><a href="173933.html#Sterilize" rel="nofollow">Sterilize</a></li><li><a href="173933.html#Begin-a-new-vial" rel="nofollow">Begin a new vial</a></li><li><a href="173933.html#Keep" rel="nofollow">Keep</a></li><li><a href="173933.html#Total-price" rel="nofollow">Total price</a></li><li><a href="173933.html#Legal" rel="nofollow">Legal</a></li></ol></li><li><a href="173933.html#Inject-yourself" rel="nofollow">Inject yourself</a><ol style=""><li><a href="173933.html#Syringes-for-injections" rel="nofollow">Syringes for injections</a></li><li><a href="173933.html#Needle-fright" rel="nofollow">Needle fright</a></li><li><a href="173933.html#Dosage" rel="nofollow">Dosage</a></li><li><a href="173933.html#How-to-inject" rel="nofollow">How to inject</a></li></ol></li><li><a href="173933.html#22Monitoring22-unnecessary" rel="nofollow">"Monitoring" unnecessary</a></li><li><a href="173933.html#Myths-and-what-not-to-do" rel="nofollow">Myths and what not to do</a></li></ol></span></div></div></div></div></div><p></p>
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<div class="panel-body" style="padding-left: 0px"><span class="toc"><ol style=""><li><a href="173933.html#Without-gatekeepers" rel="nofollow">Without gatekeepers</a></li><li><a href="173933.html#Be-your-own-endocrinologist" rel="nofollow">Be your own endocrinologist</a></li><li><a href="173933.html#Cook-your-injectable-estradiol-by-yourself" rel="nofollow">Cook your injectable estradiol by yourself</a><ol style=""><li><a href="173933.html#Buy-estradiol-enanthate-powder" rel="nofollow">Buy estradiol enanthate powder</a></li><li><a href="173933.html#Equipment" rel="nofollow">Equipment</a><ol style=""><li><a href="173933.html#Necessary" rel="nofollow">Necessary</a></li><li><a href="173933.html#Optional" rel="nofollow">Optional</a></li><li><a href="173933.html#Unnecessary" rel="nofollow">Unnecessary</a></li></ol></li><li><a href="173933.html#Other-raw-materials-and-expendables" rel="nofollow">Other raw materials and expendables</a><ol style=""><li><a href="173933.html#Vials2C-stoppers2C-caps" rel="nofollow">Vials, stoppers, caps</a></li><li><a href="173933.html#Oil" rel="nofollow">Oil</a></li><li><a href="173933.html#Preservative-28optional29" rel="nofollow">Preservative (optional)</a></li><li><a href="173933.html#Syringes-for-mixing" rel="nofollow">Syringes for mixing</a></li></ol></li><li><a href="173933.html#Mix" rel="nofollow">Mix</a></li><li><a href="173933.html#Sterilize" rel="nofollow">Sterilize</a></li><li><a href="173933.html#Begin-a-new-vial" rel="nofollow">Begin a new vial</a></li><li><a href="173933.html#Keep" rel="nofollow">Keep</a></li><li><a href="173933.html#Total-price" rel="nofollow">Total price</a></li><li><a href="173933.html#Legal" rel="nofollow">Legal</a></li></ol></li><li><a href="173933.html#Inject-yourself" rel="nofollow">Inject yourself</a><ol style=""><li><a href="173933.html#Syringes-for-injections" rel="nofollow">Syringes for injections</a></li><li><a href="173933.html#Needle-fright" rel="nofollow">Needle fright</a></li><li><a href="173933.html#Dosage" rel="nofollow">Dosage</a></li><li><a href="173933.html#How-to-inject" rel="nofollow">How to inject</a></li></ol></li><li><a href="173933.html#22Monitoring22-unnecessary" rel="nofollow">"Monitoring" unnecessary</a></li><li><a href="173933.html#Myths-and-what-not-to-do" rel="nofollow">Myths and what not to do</a></li></ol></span></div></div></div></div></div><p></p>
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<h1><a name="Without-gatekeepers"></a>Without gatekeepers</h1>
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<p>Endocrinologists usually require a letter/referral from gatekeepers: psychotherapists, psychologists, sexologists or psychiatrists. Not because endocrinologists care for you, but because they care for themselves: they fear that you regret and sue them for causing you bodily harm. There isn't a medical examination, blood or psychological test able to prove or disprove presence or absence of transsexualism in each separate person. Statistics is meaningless when the question is whether you'll regret social transition or not. So, gatekeepers make appearances of "examination" and stall you for long time while milking you (or insurance/taxpayers) for money.</p>
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<p>Medical professionals routinely make mistakes in both directions: approve crazy people and unnecessarily delay transsexuals who'll not regret.</p>
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@@ -1035,7 +1035,7 @@ function createAlert(msg, isError, autoClose, noClose) {
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<h2><a name="Equipment"></a>Equipment</h2>
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<h3><a name="Necessary"></a>Necessary</h3>
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<p>The only necessary equipment is cheap ($7 - $15) pocket 0.001 g (1 mg) scales (or DIY balance scales you can make from a long narrow wooden plank, 2 small nails and 2 syringes, one of them with 0.5 ml water as a precise weight).</p>
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<p>If you buy ready-to-use scales then they must look exactly like this:<br/><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13908/354x254.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1726620229&Signature=Y7DCUlnSHdRrOHMsvKH6LR4yv14%3D" align="right" loading="lazy" class="myimg-responsive"/><a href="https://www.ebay.com/itm/363747240371" target="_blank" rel="nofollow noopener">https://www.ebay.com/itm/363747240371</a><br/><a href="https://www.aliexpress.com/item/4000586480263.html" target="_blank" rel="nofollow noopener">https://www.aliexpress.com/item/4000586480263.html</a></p>
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<p>If you buy ready-to-use scales then they must look exactly like this:<br/><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13908/354x254.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1727225153&Signature=ScQW2YjtkYf1dnUmN2EzOysASxw%3D" align="right" loading="lazy" class="myimg-responsive"/><a href="https://www.ebay.com/itm/363747240371" target="_blank" rel="nofollow noopener">https://www.ebay.com/itm/363747240371</a><br/><a href="https://www.aliexpress.com/item/4000586480263.html" target="_blank" rel="nofollow noopener">https://www.aliexpress.com/item/4000586480263.html</a></p>
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<p>Newer models are not suitable because they attempt to appear more precise and stable by ignoring small weight changes.</p>
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<p>Search for other sellers:<br/><a href="https://www.ebay.com/sch/i.html?_nkw=scale+0.001&_sacat=0&_blrs=recall_filtering&LH_BIN=1&_sop=15&_ipg=120&_oac=1" target="_blank" rel="nofollow noopener">https://www.ebay.com/sch/i.html?_nkw=scale+0.001&_sacat=0&_blrs=recall_filtering&LH_BIN=1&_sop=15&_ipg=120&_oac=1</a></p>
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<p><a href="https://www.ebay.com/sch/i.html?_nkw=scale+digital+diamond&_sacat=0&LH_BIN=1&_sop=15&_blrs=recall_filtering&_ipg=120&_oac=1" target="_blank" rel="nofollow noopener">https://www.ebay.com/sch/i.html?_nkw=scale+digital+diamond&_sacat=0&LH_BIN=1&_sop=15&_blrs=recall_filtering&_ipg=120&_oac=1</a></p>
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@@ -1050,10 +1050,10 @@ function createAlert(msg, isError, autoClose, noClose) {
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<p>Unnecessary: beaker, mixer/stirrer, room with controlled airflow, depyrogenation. My technology: terminal heat sterilization (after the vials are sealed); measure and mix in each vial separately, so no glassware to wash with water or collecting dust (skin flakes and <a href="https://en.wikipedia.org/wiki/House_dust_mite" target="_blank" rel="nofollow noopener">mites</a>) if never washed. Water - bacteria - pyrogens. Don't try to improve this technology: it protects you from mistakes and unexpected problems.</p>
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<h2><a name="Other-raw-materials-and-expendables"></a>Other raw materials and expendables</h2>
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<h3><a name="Vials2C-stoppers2C-caps"></a>Vials, stoppers, caps</h3>
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<p><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13965/s-l300.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1726620229&Signature=U9rnobvx%2Bz5ICG8S3jHu47B%2FqVQ%3D" align="right" loading="lazy" class="myimg-responsive"/>Buy 10 clear glass vials 10 ml each with 20 mm grey (butyl rubber) stoppers and aluminium caps. Caps may be bare aluminium or painted, with plastic tops or all-metal. Screw-on and all-plastic caps are not suitable. Stoppers must have this shape:<br/><a href="https://www.ebay.com/itm/223836409810" target="_blank" rel="nofollow noopener">https://www.ebay.com/itm/223836409810</a><br/><a href="https://www.aliexpress.com/item/33024594919.html" target="_blank" rel="nofollow noopener">https://www.aliexpress.com/item/33024594919.html</a><br/>Flat septa are not suitable instead of stoppers. Search:<br/><a href="https://www.ebay.com/sch/i.html?_nkw=vial+10ml+stopper+cap&_sacat=0&LH_TitleDesc=0&LH_BIN=1&_sop=15&_oac=1" target="_blank" rel="nofollow noopener">https://www.ebay.com/sch/i.html?_nkw=vial+10ml+stopper+cap&_sacat=0&LH_TitleDesc=0&LH_BIN=1&_sop=15&_oac=1</a></p>
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<p><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13965/s-l300.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1727225153&Signature=jELhE8ayrk7wcUu%2BwmH3Z0Vhnb0%3D" align="right" loading="lazy" class="myimg-responsive"/>Buy 10 clear glass vials 10 ml each with 20 mm grey (butyl rubber) stoppers and aluminium caps. Caps may be bare aluminium or painted, with plastic tops or all-metal. Screw-on and all-plastic caps are not suitable. Stoppers must have this shape:<br/><a href="https://www.ebay.com/itm/223836409810" target="_blank" rel="nofollow noopener">https://www.ebay.com/itm/223836409810</a><br/><a href="https://www.aliexpress.com/item/33024594919.html" target="_blank" rel="nofollow noopener">https://www.aliexpress.com/item/33024594919.html</a><br/>Flat septa are not suitable instead of stoppers. Search:<br/><a href="https://www.ebay.com/sch/i.html?_nkw=vial+10ml+stopper+cap&_sacat=0&LH_TitleDesc=0&LH_BIN=1&_sop=15&_oac=1" target="_blank" rel="nofollow noopener">https://www.ebay.com/sch/i.html?_nkw=vial+10ml+stopper+cap&_sacat=0&LH_TitleDesc=0&LH_BIN=1&_sop=15&_oac=1</a></p>
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<p><a href="https://www.aliexpress.com/wholesale?SearchText=vials+10ml+stoppers+caps" target="_blank" rel="nofollow noopener">https://www.aliexpress.com/wholesale?SearchText=vials+10ml+stoppers+caps</a></p>
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<p>After you remove central part of the cap, most of the cap must remain and hold the rubber stopper at place. Caps must <strong>not</strong> have tear-off weak place on one side like this:</p>
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<p><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13909/cap-tear-off.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1726620229&Signature=rDn%2B57ihKh5Oihu7qI9toUTS4z0%3D" loading="lazy" class="myimg-responsive"/></p>
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<p><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13909/cap-tear-off.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1727225153&Signature=GRl%2BMRisWC1VQh%2FgcEytUxAtlPw%3D" loading="lazy" class="myimg-responsive"/></p>
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<p>In Europe you can buy <a href="https://lab-supply-shop.com/epages/171448.sf/en_GB/?ObjectPath=/Shops/171448/Products/%22VIC10%20000%22" target="_blank" rel="nofollow noopener">vials</a>, <a href="https://lab-supply-shop.com/epages/171448.sf/en_GB/?ObjectPath=/Shops/171448/Products/%22STG%20000%22" target="_blank" rel="nofollow noopener">stoppers</a>, <a href="https://lab-supply-shop.com/epages/171448.sf/de_DE/?ObjectPath=/Shops/171448/Products/%22BKMA%20000%22" target="_blank" rel="nofollow noopener">caps</a>, <a href="https://lab-supply-shop.com/epages/171448.sf/en_GB/?ObjectPath=/Shops/171448/Products/%22BA%20000%22" target="_blank" rel="nofollow noopener">benzyl alcohol</a> and <a href="https://lab-supply-shop.com/epages/171448.sf/en_GB/?ObjectPath=/Shops/171448/Products/%22MCT%201L%22" target="_blank" rel="nofollow noopener">MCT oil</a> in one shop.</p>
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<h3><a name="Oil"></a>Oil</h3>
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<p>MCT oil (liquid, not powder, not in capsules, without flavor added) - cheapest bottle you can find, in a local sports nutrition store or mail-order. It's the only ingredient with somewhat limited shelf life: roughly 5 years as rumored though bottles are usually marked with arbitrary shelf life 2 years. You'll use up 10 ml per year. In USA you can mail-order a 2 oz (60 ml) sample bottle <a href="https://www.ebay.com/sch/i.html?_nkw=mct+oil&_sacat=0&LH_BIN=1&_sop=15&_fcid=1&_blrs=recall_filtering&_ipg=240" target="_blank" rel="nofollow noopener">on eBay</a> for $6 including shipping. Check prices also on Amazon. In local stores smallest bottle can be 400 ml, roughly $13. MCT oil is marketed as a food supplement to be taken 15 ml/day, taken orally is rapidly absorbed. You'll inject 500 times less, so any purity is okay (it's really all the same purity despite some dishonest sellers' claims).</p>
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@@ -1065,7 +1065,7 @@ function createAlert(msg, isError, autoClose, noClose) {
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<h2><a name="Mix"></a>Mix</h2>
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<p>(See below for an alternate way without a funnel).</p>
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<p>Make a small funnel from a piece of foil (the thicker foil the better; shinier side inside), hold it folded with a small piece of sticky tape. If you have only thin foil then perhaps strengthen it by wide sticky tape on another side (or try to strip the outer paint from a few different beer or soft drink aluminium cans with nail polish remover, then cut a clean can with scissors). May be use something conical to wrap the foil around before cutting off unneeded parts. The hole at the pointy end of the funnel must be slightly (not much) smaller than the opening in the vial. Use this funnel to weigh up estradiol enanthate powder and to pour the powder into a vial. The funnel I'm using at the center, unfolded piece of foil from my previous funnel at the left, a funnel in a vial at the right:</p>
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<p><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13910/cone.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1726620229&Signature=qGwZAGsuaBtYG31DYyESYIkWJuU%3D" loading="lazy" class="myimg-responsive"/></p>
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<p><img src="https://s3-us-west-1.amazonaws.com/groupsiowikiimages/4415/13910/cone.jpg?AWSAccessKeyId=AKIAJECNKOVMCCU3ATNQ&Expires=1727225153&Signature=xWXWC6CdfeXfkzRQ1hS2yJAYpMg%3D" loading="lazy" class="myimg-responsive"/></p>
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<p>Two recipes I can recommend:</p>
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<p>1) 500 mg = 0.5 g of estradiol enanthate (density 1.1 g/cm<sup><small>3</small></sup>),<br/>benzyl alcohol (preservative - antibacterial) 0.2 ml,<br/>MCT oil 10-0.2-0.5/1.1= 9.35 ml.</p>
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<p>2) 0.5 g of estradiol enanthate,<br/>MCT oil 10-0.5/1.1= 9.55 ml.</p>
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@@ -1114,7 +1114,7 @@ function createAlert(msg, isError, autoClose, noClose) {
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<p>I recommend to inject 0.22 ml (22 units on U-100 insulin syringe scale or 8 units if U-40) weekly (on the same day of every week) or 0.31 ml every 10 days (on 1, 11, 21 of every month). The same dosage from the very beginning of MtF HRT and all the time later, post-op too, never stop. I chose this dosage to advise so that it's enough for complete suppression of testosterone production by testicles in any MtF. On the same dosage of the same hormone different people get trough blood estradiol level (just before next injection) differing in up to 10 times. Also, sensitivity of different people to the same level of the same hormone differs in times. Sensitivity is as important as levels. There isn't a test for sensitivity. So, why do doctors prescribe blood tests to MtF? Just to impress naive patients and to keep themselves busy and paid. For most MtF the dosage I advise is more than enough, but so what? It's laughably cheap. For a few this dosage is barely enough, so don't gamble and don't waste time. A few blood tests would be more expensive than all the hormone you'll ever take, so why bother? Doctors love to tell bogeyman stories about side effects - just to scare you into blood tests and - paying them for more doctor visits.</p>
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<p>If a doctor sees results of your blood tests, likely he'll claim "too much estradiol, dangerous". Then give him the <a href="https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-1001723" target="_blank" rel="nofollow noopener">link</a> to a scientific article describing how doctors injected women with 4 times higher estradiol dosage than I advise, those women got blood estradiol level roughly 3000 pg/ml = 11000 pmol/l in average. Full text of that article can be accessed via <a href="https://en.wikipedia.org/wiki/Sci-Hub" target="_blank" rel="nofollow noopener">Sci-Hub</a>, or members of this [MTFHRT] group can read it <a href="https://groups.io/g/MTFHRT/files/estrogens/ulrich1994.pdf" target="_blank" rel="nofollow noopener">here</a>. I quote that article:</p>
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<blockquote>
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<p><span style="font-size: 15px; font-family: serif;">The treatment was well tolerated. No adverse </span><span style="font-size: 15px; font-family: serif;">effects were seen, the patients expressed a feeling of particular </span><span style="font-size: 15px; font-family: serif;">well being, 23% of them wanted to have the injections repeated and </span><span style="font-size: 15px; font-family: serif;">none of them wanted to stop treatment because of troubles or </span><span style="font-size: 15px; font-family: serif;">side effects.</span></p>
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<p><span style="font-size: 15px; font-family: serif">The treatment was well tolerated. No adverse </span><span style="font-size: 15px; font-family: serif">effects were seen, the patients expressed a feeling of particular </span><span style="font-size: 15px; font-family: serif">well being, 23% of them wanted to have the injections repeated and </span><span style="font-size: 15px; font-family: serif">none of them wanted to stop treatment because of troubles or </span><span style="font-size: 15px; font-family: serif">side effects.</span></p>
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</blockquote>
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<p>That's on 4 times higher estradiol dosage than I advise.</p>
|
||||
<h2><a name="How-to-inject"></a>How to inject</h2>
|
||||
@@ -1133,27 +1133,27 @@ function createAlert(msg, isError, autoClose, noClose) {
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<p>Any estradiol (E2) level between 300 and 5000 pg/ml (1100 - 18000 pmol/l) is okay for both pre-ops and post-ops. Estrone (E1) level doesn't matter. All doctors' assertions "too much" are bullshit meant to control us and extort money under guise of "care". The only reasonable cause to do a blood test for estradiol (once, at least a month after first injection, only on a day of next injection before it) is your peace of mind that you got indeed estradiol enanthate. But above I described two other ways to check that, and likely you'll experience pain in breast buds. I tested a new batch of estradiol enanthate powder on myself, my blood estradiol level was 1272 pg/ml = 4670 pmol/l 5 days after an injection. I had SRS in 1999, I needn't to suppress testosterone. Nevertheless, I don't intend to decrease my dosage. It slows down aging, on it I look and feel better.</p>
|
||||
<h1><a name="Myths-and-what-not-to-do"></a>Myths and what not to do</h1>
|
||||
<p>Above I explained about some myths and fallacies. Some more:</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">discard a vial 30 days after you began it</span>. Bureaucrats get their salaries for inventing new rules, no matter how unreasonable. This rule was invented for hospitals with multiple patients (some with infectious diseases), not for your home.</p>
|
||||
<p>Fallacy: <span style="background-color: #ff99cc;">use separate needles for drawing and injection</span>. It's easy to bend needle tip on hard glass ampule bottom while drawing from an all-glass single-dose ampule, it's where the myth of "needle blunting" originates. Insulin syringes with non-detachable needles are designed for insulin vials also with rubber stoppers.</p>
|
||||
<p>If an average doctor prescribes injectable estradiol, he says nothing about needles, he says "<span style="background-color: #ff99cc;">inject into muscle</span>" because the gospel (instructions sold with injectable estradiol) says so (without explanation why - really it's because the solvent used with EV sometimes causes allergy, then IM helps). You go to a pharmacy and ask for intramuscular injections. An average pharmacist asks you for injection volume (less than 1 ml) and sells you 2 ml syringes, each syringe comes with a needle in the same pack. Manufacturers put long needles with 10 ml syringes and shorter needles with 2 ml syringes. Why? Aesthetics. :-/ You get syringes with dead space and needles 25 mm long, you inject into buttock. You, pharmacist, nurse and doctor think that you inject into muscle. Really fat layer in buttocks is thicker even in very skinny people. You in fact inject into fat. And... it works. Gospels are full of fallacies.</p>
|
||||
<p>Fallacy: after sticking the needle in your skin, <span style="background-color: #ff99cc;">you must aspirate to check whether you hit a blood vessel</span>. There aren't significant blood vessels in buttocks at 13 mm (1/2") depth. If you aspirate, you wound yourself because of inevitable needle movements sideways.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">discard a vial 30 days after you began it</span>. Bureaucrats get their salaries for inventing new rules, no matter how unreasonable. This rule was invented for hospitals with multiple patients (some with infectious diseases), not for your home.</p>
|
||||
<p>Fallacy: <span style="background-color: #ff99cc">use separate needles for drawing and injection</span>. It's easy to bend needle tip on hard glass ampule bottom while drawing from an all-glass single-dose ampule, it's where the myth of "needle blunting" originates. Insulin syringes with non-detachable needles are designed for insulin vials also with rubber stoppers.</p>
|
||||
<p>If an average doctor prescribes injectable estradiol, he says nothing about needles, he says "<span style="background-color: #ff99cc">inject into muscle</span>" because the gospel (instructions sold with injectable estradiol) says so (without explanation why - really it's because the solvent used with EV sometimes causes allergy, then IM helps). You go to a pharmacy and ask for intramuscular injections. An average pharmacist asks you for injection volume (less than 1 ml) and sells you 2 ml syringes, each syringe comes with a needle in the same pack. Manufacturers put long needles with 10 ml syringes and shorter needles with 2 ml syringes. Why? Aesthetics. :-/ You get syringes with dead space and needles 25 mm long, you inject into buttock. You, pharmacist, nurse and doctor think that you inject into muscle. Really fat layer in buttocks is thicker even in very skinny people. You in fact inject into fat. And... it works. Gospels are full of fallacies.</p>
|
||||
<p>Fallacy: after sticking the needle in your skin, <span style="background-color: #ff99cc">you must aspirate to check whether you hit a blood vessel</span>. There aren't significant blood vessels in buttocks at 13 mm (1/2") depth. If you aspirate, you wound yourself because of inevitable needle movements sideways.</p>
|
||||
<p>Don't give a vial into the hands of a doctor, he'd destroy it. Doctors are jealous.</p>
|
||||
<p>Don't use an emulator (calculator of blood levels). It uses average statistical data, but <strong>you</strong> are not a statistically average person.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">begin from pills (low dosage), then after some time switch to injections</span>. Doctors love to begin from low dosage because that keeps them busy and paid. So they invent explanations why it's allegedly better. People repeat doctor claims.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">decrease estrogen dosage post-op</span>. Estrogen dosages described in pharmaceutical reference books (collections of package inserts) for men with prostatic cancer are higher (designed to suppress testosterone production by testicles) than for women (after menopause) - limited in the fear of uterine cancer. Only after SRS we magically become women in doctors' eyes.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">"estrogens" increase risk of blood clots, take Aspirin to counteract that</span>. Ethinylestradiol increases risk of venous thrombosis, Aspirin decreases risk of arterial thrombosis in coronal arteries in the heart. Combination of ethinylestradiol with Aspirin is like wearing a flak jacket while going against a gas attack. Don't confuse ethinylestradiol (EE) with estradiol enanthate (EEn). Unlike ethinylestradiol, injectable estradiol practically doesn't affect risk of thrombosis. Did you know that thrombosis risk depends (among other things) on whether your blood is type 0(1) or any other type ("non-zero")? Estradiol enanthate dosage I advise affects blood clotting less.</p>
|
||||
<p>Fallacy: <span style="background-color: #ff99cc;">stop "hormones" some time before SRS or another surgery, resume only some time later</span>. Surgeons don't know and don't want to know differences between various estrogens and routes of their delivery. Ethinylestradiol in combination with bloodflow in immobile legs stopped by stirrups (to move legs out of surgeon's way during SRS) can cause deep vein thrombosis and deadly pulmonary embolism as a consequence. Don't try to explain to the surgeon that injectable estradiol doesn't do that, tell that you comply but silently continue injections for your passability and mood not to worsen. Blood tests surgeons require check some blood clotting parameters, not estradiol.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">libido and erections are signs of testosterone</span>. In many MtF estradiol dosage I advise stimulates libido and erections though suppresses testosterone production by testicles completely. If still in doubt, do a blood test for testosterone on a day of next injection before it. Cis-women (and post-SRS MtF) get erections of clitoris - exactly same mechanism as erections of penis.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">excess estrogen is converted to testosterone</span>. The conversion estrone<->estradiol is bidirectional, but the conversion testosterone->estradiol is strictly <a href="https://www.genome.jp/kegg-bin/show_pathway?hsa00140" target="_blank" rel="nofollow noopener">unidirectional</a>.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">if you take too much estradiol then SHBG will bind it and make it unusable</span>. If estradiol level increases, liver produces more SHBG. Nevertheless, free estradiol level increases too.</p>
|
||||
<p>Words "<span style="background-color: #ff99cc;">estrogen dominance</span>" were invented by marketers of progesterone and quackeries they call progesterone bla-bla-something like "Wild Yam". Long ago progesterone was produced chemically from wild yam, but human body cannot perform that chemical conversion.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">begin from pills (low dosage), then after some time switch to injections</span>. Doctors love to begin from low dosage because that keeps them busy and paid. So they invent explanations why it's allegedly better. People repeat doctor claims.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">decrease estrogen dosage post-op</span>. Estrogen dosages described in pharmaceutical reference books (collections of package inserts) for men with prostatic cancer are higher (designed to suppress testosterone production by testicles) than for women (after menopause) - limited in the fear of uterine cancer. Only after SRS we magically become women in doctors' eyes.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">"estrogens" increase risk of blood clots, take Aspirin to counteract that</span>. Ethinylestradiol increases risk of venous thrombosis, Aspirin decreases risk of arterial thrombosis in coronal arteries in the heart. Combination of ethinylestradiol with Aspirin is like wearing a flak jacket while going against a gas attack. Don't confuse ethinylestradiol (EE) with estradiol enanthate (EEn). Unlike ethinylestradiol, injectable estradiol practically doesn't affect risk of thrombosis. Did you know that thrombosis risk depends (among other things) on whether your blood is type 0(1) or any other type ("non-zero")? Estradiol enanthate dosage I advise affects blood clotting less.</p>
|
||||
<p>Fallacy: <span style="background-color: #ff99cc">stop "hormones" some time before SRS or another surgery, resume only some time later</span>. Surgeons don't know and don't want to know differences between various estrogens and routes of their delivery. Ethinylestradiol in combination with bloodflow in immobile legs stopped by stirrups (to move legs out of surgeon's way during SRS) can cause deep vein thrombosis and deadly pulmonary embolism as a consequence. Don't try to explain to the surgeon that injectable estradiol doesn't do that, tell that you comply but silently continue injections for your passability and mood not to worsen. Blood tests surgeons require check some blood clotting parameters, not estradiol.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">libido and erections are signs of testosterone</span>. In many MtF estradiol dosage I advise stimulates libido and erections though suppresses testosterone production by testicles completely. If still in doubt, do a blood test for testosterone on a day of next injection before it. Cis-women (and post-SRS MtF) get erections of clitoris - exactly same mechanism as erections of penis.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">excess estrogen is converted to testosterone</span>. The conversion estrone<->estradiol is bidirectional, but the conversion testosterone->estradiol is strictly <a href="https://www.genome.jp/kegg-bin/show_pathway?hsa00140" target="_blank" rel="nofollow noopener">unidirectional</a>.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">if you take too much estradiol then SHBG will bind it and make it unusable</span>. If estradiol level increases, liver produces more SHBG. Nevertheless, free estradiol level increases too.</p>
|
||||
<p>Words "<span style="background-color: #ff99cc">estrogen dominance</span>" were invented by marketers of progesterone and quackeries they call progesterone bla-bla-something like "Wild Yam". Long ago progesterone was produced chemically from wild yam, but human body cannot perform that chemical conversion.</p>
|
||||
<p>If you are wondering about real progesterone:</p>
|
||||
<p>1) Injectable progesterone is very short-living, must be injected daily. Oral progesterone is ineffective because most of it is converted to allopregnanolone which common blood tests confuse with progesterone. Hydroxyprogesterone caproate is not bioidentical, it's not converted in the body to progesterone (unlike estradiol valerate and estradiol enanthate).</p>
|
||||
<p>2) Progesterone decreases rate of synthesis of estrogen receptors. Cis-women are supposed to benefit from that, but goals of MtF are opposite.</p>
|
||||
<p>3) Estradiol develops ducts in milk glands, progesterone develops alveoles. Most of breast volume is ducts and connective tissue between them. If an alveole formed (at the end of a duct), that duct will not grow in length anymore. So, progesterone can stunt breast growth. Cyproterone acetate too, it's a strong progestogen.</p>
|
||||
<p>I advise <strong>not</strong> to add progesterone for at least 3 years since starting estradiol injections at least 40 mg/month (<strong>not</strong> since the very beginning of HRT). Or never add progesterone. Though progesterone is a female hormone, that doesn't mean that it's beneficial for MtF (no uterus).</p>
|
||||
<p>Myth: an article linked from Wikipedia <span style="background-color: #ff99cc;">claimed a case of prolactinoma as a side effect of estradiol enanthate</span>. Actually factory-made injections with estradiol enanthate always contain also high dosage of a progestin. Cyproterone acetate is a strong progestin and is known to cause prolactinoma. One more reason to never add progesterone if you haven't an uterus.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc;">compounding pharmacies make superior products</span>. If you get exceptionally lucky and find a doctor willing to prescribe as high injectable estradiol dosage as I advise who doesn't freak out at blood test results (you'd have to pay to gatekeeprs, doctor, pharmacy and labs), compounding pharmacies in few countries can cook injectable estradiol with prescription. No compounding pharmacy would have estradiol enanthate powder, and I doubt that they can make estradiol cypionate (EC) 50 mg/ml because factory-made EC is 5 mg/ml max. They cannot make more than 10 mg/ml without solvent (benzyl benzoate) which can cause allergy. They use other oils which also cause allergy more often than MCT oil. But the main their problem is that they never mix in each vial separately and often repeat Indian factories' mistake I described above: undissolved powder gets stuck in a filter, so you get much less estradiol than prescribed (often happens in Canada). Another example of their stupidity: a compounding ("Galenic") pharmacy in Italy <a href="https://imgur.com/a/pmOmypJ" target="_blank" rel="nofollow noopener">used</a> ethoxylated Castor oil (essentially a soap) instead of plain Castor oil, so of course injections hurt immensely and were ineffective. If you want it to be done right, Do It Yourself.</p>
|
||||
<p>Myth: an article linked from Wikipedia <span style="background-color: #ff99cc">claimed a case of prolactinoma as a side effect of estradiol enanthate</span>. Actually factory-made injections with estradiol enanthate always contain also high dosage of a progestin. Cyproterone acetate is a strong progestin and is known to cause prolactinoma. One more reason to never add progesterone if you haven't an uterus.</p>
|
||||
<p>Myth: <span style="background-color: #ff99cc">compounding pharmacies make superior products</span>. If you get exceptionally lucky and find a doctor willing to prescribe as high injectable estradiol dosage as I advise who doesn't freak out at blood test results (you'd have to pay to gatekeeprs, doctor, pharmacy and labs), compounding pharmacies in few countries can cook injectable estradiol with prescription. No compounding pharmacy would have estradiol enanthate powder, and I doubt that they can make estradiol cypionate (EC) 50 mg/ml because factory-made EC is 5 mg/ml max. They cannot make more than 10 mg/ml without solvent (benzyl benzoate) which can cause allergy. They use other oils which also cause allergy more often than MCT oil. But the main their problem is that they never mix in each vial separately and often repeat Indian factories' mistake I described above: undissolved powder gets stuck in a filter, so you get much less estradiol than prescribed (often happens in Canada). Another example of their stupidity: a compounding ("Galenic") pharmacy in Italy <a href="https://imgur.com/a/pmOmypJ" target="_blank" rel="nofollow noopener">used</a> ethoxylated Castor oil (essentially a soap) instead of plain Castor oil, so of course injections hurt immensely and were ineffective. If you want it to be done right, Do It Yourself.</p>
|
||||
<hr/>
|
||||
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Reference in New Issue
Block a user